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KMID : 0352819850010010049
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Kosin Medical Journal
1985 Volume.1 No. 1 p.49 ~ p.56
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A Case of Surgical Treatment in Myasthenia Gravis with Thymoma
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조성래/Cho, Sung Rae
김송명/허만하/Kim, Song Myung/Huh, man Ha
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Abstract
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Myasthenia gravis is a disorder of neuromuscular transmission characterized by fatigability and weakness of voluntary muscles. As recent investigations have suggested an immune basis for this disease, the basic defect in the myasthenia gravis is reduction of available acetylcholine receptors at neuromuscular junction by an immune attack.
Surgical interest in this disease was first aroused in 1939 when Blalock observed that patient with thymic tumor and myasthenia gravis combined thymoma.
The 26yearold woman was admitted to the Kosin Medical College Hospital because of general weakness, bilateral ptosis, and swallowing difficulties, which were relieved by administration of Tensilon, given intravenously. The presence of thymoma was suggested by roentgenographic studies.
We performed removal of thymoma and total thymectomy, and immediated postoperative tracheostomy was performed and ventilatory assist was given for 7 days. The patient was completely recovered with small amount of anticholinestrase drug only.
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